Hong Kong Mood Disorders Center, Prince of Wales Hospital, Shatin, NT, Hong Kong.
Br J Psychiatry. 2010 Mar;196(3):217-25. doi: 10.1192/bjp.bp.109.067843.
The epidemiology of rapid-cycling bipolar disorder in the community is largely unknown.
To investigate the epidemiological characteristics of rapid-cycling and non-rapid-cycling bipolar disorder in a large cross-national community sample.
The Composite International Diagnostic Interview (CIDI version 3.0) was used to examine the prevalence, severity, comorbidity, impairment, suicidality, sociodemographics, childhood adversity and treatment of rapid-cycling and non-rapid-cycling bipolar disorder in ten countries (n = 54 257).
The 12-month prevalence of rapid-cycling bipolar disorder was 0.3%. Roughly a third and two-fifths of participants with lifetime and 12-month bipolar disorder respectively met criteria for rapid cycling. Compared with the non-rapid-cycling, rapid-cycling bipolar disorder was associated with younger age at onset, higher persistence, more severe depressive symptoms, greater impairment from depressive symptoms, more out-of-role days from mania/hypomania, more anxiety disorders and an increased likelihood of using health services. Associations regarding childhood, family and other sociodemographic correlates were less clear cut.
The community epidemiological profile of rapid-cycling bipolar disorder confirms most but not all current clinically based knowledge about the illness.
社区中快速循环双相障碍的流行病学情况在很大程度上尚不清楚。
在一个大型跨国社区样本中调查快速循环和非快速循环双相障碍的流行病学特征。
使用复合国际诊断访谈（CIDI 版本 3.0）来检查十种国家（n=54257）中快速循环和非快速循环双相障碍的患病率、严重程度、共病、功能损害、自杀倾向、社会人口统计学、儿童期逆境和治疗情况。
双相障碍的 12 个月患病率为 0.3%。大约三分之一和五分之二的终身和 12 个月双相障碍患者分别符合快速循环的标准。与非快速循环相比，快速循环双相障碍与发病年龄较早、持续性更高、抑郁症状更严重、抑郁症状所致功能损害更大、躁狂/轻躁狂期角色外天数更多、焦虑障碍更多以及更有可能使用卫生服务相关。关于儿童期、家庭和其他社会人口统计学相关因素的关联则不太明确。
快速循环双相障碍的社区流行病学特征证实了目前大多数但并非所有基于临床的疾病知识。
