蛋白质结构与二硫键连接模式之间的关系。
Relationship between protein structures and disulfide-bonding patterns.
作者信息
Chuang Chao-Chun, Chen Chun-Yin, Yang Jinn-Moon, Lyu Ping-Chiang, Hwang Jenn-Kang
机构信息
Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan.
出版信息
Proteins. 2003 Oct 1;53(1):1-5. doi: 10.1002/prot.10492.
We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling.
我们发现二硫键连接模式可用于区分结构相似性。我们基于层次聚类方案的方法适用于具有两个或更多二硫键的蛋白质，并且能够检测低序列同一性（<25%）蛋白质的结构相似性。我们的结果表明二硫键连接模式与蛋白质结构之间存在惊人的紧密关系。我们的发现应有助于蛋白质结构建模。
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