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DBCP:一种无需事先了解半胱氨酸键合状态的二硫键连接模式预测的网络服务器。

DBCP: a web server for disulfide bonding connectivity pattern prediction without the prior knowledge of the bonding state of cysteines.

机构信息

Department of Applied Mathematics, National Chung Hsing University, Taiwan, ROC.

出版信息

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W503-7. doi: 10.1093/nar/gkq514. Epub 2010 Jun 8.

Abstract

The proper prediction of the location of disulfide bridges is efficient in helping to solve the protein folding problem. Most of the previous works on the prediction of disulfide connectivity pattern use the prior knowledge of the bonding state of cysteines. The DBCP web server provides prediction of disulfide bonding connectivity pattern without the prior knowledge of the bonding state of cysteines. The method used in this server improves the accuracy of disulfide connectivity pattern prediction (Q(p)) over the previous studies reported in the literature. This DBCP server can be accessed at http://120.107.8.16/dbcp or http://140.120.14.136/dbcp.

摘要

正确预测二硫键的位置有助于解决蛋白质折叠问题。以前大多数关于二硫键连接模式预测的工作都利用了半胱氨酸键合状态的先验知识。DBCP 网络服务器提供了无需半胱氨酸键合状态先验知识的二硫键连接模式预测。该服务器中使用的方法提高了二硫键连接模式预测的准确性(Q(p)),超过了文献中以前报道的研究。该 DBCP 服务器可在以下网址访问:http://120.107.8.16/dbcphttp://140.120.14.136/dbcp。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a1/2896133/6586ca6c9f4a/gkq514f1.jpg

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