Wang Emily, Verhagen Metman Leo, Bakay Roy, Arzbaecher Jean, Bernard Bryan
Department of Communication Disorders and Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.
Clin Linguist Phon. 2003 Jun-Aug;17(4-5):283-9. doi: 10.1080/0269920031000080064.
This paper reports findings on the respiratory/phonatory subsystems from an on-going study investigating the effect of unilateral electrostimulation of the subthalamic nucleus (STN) on different speech subsystems in people with Parkinson's disease (PD). Speech recordings were made in the medication-off state at baseline, three months post surgery with stimulation-on, and with stimulation-off, in six right-handed PD patients. Subjects completed several speech tasks. Acoustic analyses of the maximally sustained vowel phonation were reported. The results were compared to the scores of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS-III) obtained under the same conditions. Results showed that stimulation-on improved UPDRS-III scores in all six subjects. While mild improvement was observed for all subjects in the Stimulation-on condition, three subjects received left-STN stimulation showed a significant decline in vocal intensity and vowel duration from their baseline indicating the speech function was very susceptible to micro lesions due to the surgical procedure itself when the surgical site was in the dominant hemisphere.
本文报告了一项正在进行的研究中关于呼吸/发声子系统的研究结果，该研究旨在调查丘脑底核（STN）单侧电刺激对帕金森病（PD）患者不同言语子系统的影响。对6名右利手PD患者在基线期药物未服用状态、术后3个月刺激开启状态和刺激关闭状态下进行了语音记录。受试者完成了多项言语任务。报告了对最大持续元音发声的声学分析结果。将结果与在相同条件下获得的统一帕金森病评定量表（UPDRS-III）运动部分的评分进行了比较。结果显示，刺激开启状态下所有6名受试者的UPDRS-III评分均有所改善。虽然在刺激开启状态下所有受试者都有轻度改善，但接受左侧STN刺激的3名受试者的嗓音强度和元音时长较基线期显著下降，这表明当手术部位位于优势半球时，由于手术本身导致的微小损伤，言语功能非常容易受到影响。
