Kron B
Centre Hospitalier Privé des Yvelines, Sartrouville.
J Chir (Paris). 1992 Oct;129(10):414-9.
The interest of surgical prostheses in the palliative treatment of biliary tract cancer is well established, on the basis of their good tolerance, the more than 15 year follow up experience and the number of patients operated upon. After exeresis, they allow re-establishment of continuity, either by use of a prosthesis in Y when the right and let ducts can be dissected, or by using two prostheses, a multiperforated long prosthesis reimplanted in the duodenum and a short prosthesis reimplanted in the common bile duct without attaining the sphincter of Oddi. Of the 1000 cases treated, 500 were the object of a statistical analysis, 46 being operated upon by the author, in 60% of cases for biliary tract cancer, either primary or as an extension from the gallbladder. One-third of the patients had advanced lesions and a short survival of less than 3 months. Two-thirds a median survival of 9 months. In 10%, a radical exeresis was performed with survival of more than one year without recurrence of jaundice. Failure of treatment with persistence of jaundice was due to advanced disease for which surgery is unsatisfactory. Essential complications were premature bile leaks (5%) without serious consequences if sufficient drainage was maintained, since it stopped spontaneously, and angiocholitis (6%), the result of territory exclusion or reflux. Recurrence of jaundice was related to extension of the neoplasm to the secondary bile ducts, and to hepatic metastases. Obstruction of the prosthesis before two months was rare (6%) and was preceded by angiocholitis. In the absence of recurrence of the cancer the prosthesis can be replaced surgically without difficulty.
基于手术假体良好的耐受性、超过15年的随访经验以及接受手术的患者数量,其在胆管癌姑息治疗中的作用已得到充分证实。切除术后,可通过以下方式重建连续性:当左右肝管可分离时,使用Y形假体;或使用两个假体,一个多孔长假体重新植入十二指肠,一个短假体重新植入胆总管但不触及Oddi括约肌。在治疗的1000例病例中,500例进行了统计分析,其中46例由作者实施手术,60%的病例为胆管癌,包括原发性或胆囊癌的延伸。三分之一的患者有晚期病变,生存期短于3个月。三分之二的患者中位生存期为9个月。10%的患者进行了根治性切除,生存期超过一年且无黄疸复发。治疗失败且黄疸持续是由于疾病进展导致手术效果不佳。主要并发症为早期胆漏(5%),如果保持充分引流,不会产生严重后果,因为胆漏会自行停止;还有胆管炎(6%),是区域排除或反流的结果。黄疸复发与肿瘤扩展至二级胆管以及肝转移有关。假体在两个月前阻塞的情况很少见(6%),且之前会出现胆管炎。在癌症无复发的情况下,可通过手术轻松更换假体。