用于制备3-烯基吡咯烷的分子内碳锂化反应。
Intramolecular carbolithiation reactions for the preparation of 3-alkenylpyrrolidines.
作者信息
Coldham Iain, Price Kathy N, Rathmell Richard E
机构信息
School of Chemistry, University of Exeter, Stocker Road, Exeter, UK EX4 4QD.
出版信息
Org Biomol Chem. 2003 Jun 21;1(12):2111-9. doi: 10.1039/b303670g.
DOI:10.1039/b303670g
PMID:12945902
Abstract
Tin-lithium exchange allows the formation of alpha-amino-organolithium species that undergo anionic cyclization onto allylic ethers to give 3-alkenylpyrrolidines. The methodology has been applied to the synthesis of an advanced intermediate related to the natural product (-)-alpha-kainic acid.
摘要
锡-锂交换反应能够形成α-氨基有机锂物种，该物种可与烯丙基醚发生阴离子环化反应生成3-烯基吡咯烷。该方法已应用于与天然产物（-）-α-红藻氨酸相关的一种高级中间体的合成。
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