Coldham Iain, Price Kathy N, Rathmell Richard E
School of Chemistry, University of Exeter, Stocker Road, Exeter, UK EX4 4QD.
Org Biomol Chem. 2003 Jun 21;1(12):2111-9. doi: 10.1039/b303670g.
Tin-lithium exchange allows the formation of alpha-amino-organolithium species that undergo anionic cyclization onto allylic ethers to give 3-alkenylpyrrolidines. The methodology has been applied to the synthesis of an advanced intermediate related to the natural product (-)-alpha-kainic acid.
锡-锂交换反应能够形成α-氨基有机锂物种，该物种可与烯丙基醚发生阴离子环化反应生成3-烯基吡咯烷。该方法已应用于与天然产物（-）-α-红藻氨酸相关的一种高级中间体的合成。
