Wada Shinobu, Hayashi Nobuyuki, Suzuki Hitomi
Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Gakuen 2-1, Sanda 669-1337, Japan.
Org Biomol Chem. 2003 Jun 21;1(12):2160-3. doi: 10.1039/b303783e.
When milled together with bismuth shot in the presence of allyl halide, aromatic aldehydes readily underwent a Barbier-type allylation to afford the corresponding homoallyl alcohols in good yield. In contrast to the failure in solution reaction, aromatic ketones also underwent allylic carbonyl addition under solvent-free conditions to give the expected tertiary homoallyl alcohols in moderate to good yield.
在卤代烯丙基存在下与铋丸一起研磨时，芳香醛很容易发生巴比耶型烯丙基化反应，以良好的产率得到相应的高烯丙醇。与溶液反应失败不同，芳香酮在无溶剂条件下也能发生烯丙基羰基加成反应，以中等至良好的产率得到预期的叔高烯丙醇。
