在无溶剂条件下，铋介导的芳香羰基化合物的巴比耶型烯丙基化反应有明显的促进作用。
Noticeable facilitation of the bismuth-mediated Barbier-type allylation of aromatic carbonyl compounds under solvent-free conditions.
作者信息
Wada Shinobu, Hayashi Nobuyuki, Suzuki Hitomi
机构信息
Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Gakuen 2-1, Sanda 669-1337, Japan.
出版信息
Org Biomol Chem. 2003 Jun 21;1(12):2160-3. doi: 10.1039/b303783e.
DOI:10.1039/b303783e
PMID:12945908
Abstract
When milled together with bismuth shot in the presence of allyl halide, aromatic aldehydes readily underwent a Barbier-type allylation to afford the corresponding homoallyl alcohols in good yield. In contrast to the failure in solution reaction, aromatic ketones also underwent allylic carbonyl addition under solvent-free conditions to give the expected tertiary homoallyl alcohols in moderate to good yield.
摘要
在卤代烯丙基存在下与铋丸一起研磨时，芳香醛很容易发生巴比耶型烯丙基化反应，以良好的产率得到相应的高烯丙醇。与溶液反应失败不同，芳香酮在无溶剂条件下也能发生烯丙基羰基加成反应，以中等至良好的产率得到预期的叔高烯丙醇。
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