Wu Xizeng, Liu Hong
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Med Phys. 2003 Aug;30(8):2169-79. doi: 10.1118/1.1593836.
Theoretical foundation and design considerations of a clinical feasible x-ray phase contrast imaging technique were presented in this paper. Different from the analysis of imaging phase object with weak absorption in literature, we proposed a new formalism for in-line phase-contrast imaging to analyze the effects of four clinically important factors on the phase contrast. These are the body parts attenuation, the spatial coherence of spherical waves from a finite-size focal spot, and polychromatic x-ray and radiation doses to patients for clinical applications. The theory presented in this paper can be applied widely in diagnostic x-ray imaging procedures. As an example, computer simulations were conducted and optimal design parameters were derived for clinical mammography. The results of phantom experiments were also presented which validated the theoretical analysis and computer simulations.
本文介绍了一种临床可行的X射线相衬成像技术的理论基础和设计考量。与文献中对弱吸收成像相位物体的分析不同，我们提出了一种用于同轴相衬成像的新形式，以分析四个临床重要因素对相衬的影响。这些因素包括身体部位的衰减、来自有限尺寸焦点的球面波的空间相干性、多色X射线以及临床应用中对患者的辐射剂量。本文提出的理论可广泛应用于诊断性X射线成像程序。作为一个例子，进行了计算机模拟，并得出了用于临床乳腺摄影的最佳设计参数。还给出了体模实验结果，验证了理论分析和计算机模拟。
