酵母端粒复合体：组成成分及其功能。

Yeast telosome complex: components and their functions.

作者信息

Dmitriev P V, Petrov A V, Dontsova O A

机构信息

School of Chemistry, Lomonosov Moscow State University, Moscow, 119899, Russia.

出版信息

Biochemistry (Mosc). 2003 Jul;68(7):718-34. doi: 10.1023/a:1025022630840.

DOI:10.1023/a:1025022630840

PMID:12946253

Abstract

Telomeres are multi-component DNA-protein complexes protecting linear chromosome termini against degradation and fusion. Telomeres and their components are involved in many essential processes: control of cell division number, regulation of transcription, reparation. They are necessary for correct chromosome segregation during cell division. Telomere protein content and DNA length are under control of different factors, such as components of replication and reparation machinery and cell division cycle kinases. Here we discuss the participation of components of yeast telomere (telosome complex) in different cellular processes, telomeric DNA length regulation pathways, and some issues of telosome evolution.

摘要

端粒是多组分的DNA-蛋白质复合物，可保护线性染色体末端免于降解和融合。端粒及其组分参与许多重要过程：细胞分裂次数的控制、转录调控、修复。它们对于细胞分裂过程中染色体的正确分离是必需的。端粒蛋白质含量和DNA长度受不同因素控制，如复制和修复机制的组分以及细胞分裂周期激酶。在这里，我们讨论酵母端粒（端粒体复合物）的组分在不同细胞过程中的参与情况、端粒DNA长度调控途径以及端粒体进化的一些问题。