走向酵母端粒动力学的机制。
Towards the Mechanism of Yeast Telomere Dynamics.
机构信息
Department of Biochemistry and Molecular Biology, Tulane University Medical School, New Orleans, LA, USA.
出版信息
Trends Cell Biol. 2019 May;29(5):361-370. doi: 10.1016/j.tcb.2019.01.005. Epub 2019 Feb 11.
Abstract
A mechanistic understanding of the yeast telomere requires an integrated understanding of telomere chromatin structure (telosomes), telomeric origins of replications, telomere length homeostasis, and telosome epigenetics. Recent molecular and genetic studies of the yeast telosomal components Rap1, Rif1, and Rif2, the Mre11 complex, and Tel1 promise to increase our insight into the coordination between these processes. Here, an intricate relationship is proposed between these multiple components that has resulted in increased appreciation of the multiple levels of telomere length control and their differentiation from double-strand repair. The mre11A470 motif (A470-A482) alleles have also opened new avenues to the exploration of telosome structure and function.
摘要
对酵母端粒的机制理解需要综合理解端粒染色质结构（端粒体）、端粒复制起点、端粒长度稳态和端粒体表观遗传学。最近对酵母端粒体成分 Rap1、Rif1 和 Rif2、Mre11 复合物和 Tel1 的分子和遗传研究有望增加我们对这些过程之间协调的认识。在这里，提出了这些多个组件之间的复杂关系，这导致了对端粒长度控制的多个层次的增加理解及其与双链修复的区别。mre11A470 基序（A470-A482）等位基因也为探索端粒体结构和功能开辟了新途径。
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2
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Mol Cell. 2018 Aug 2;71(3):419-427. doi: 10.1016/j.molcel.2018.06.033. Epub 2018 Jul 26.
3
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4
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Annu Rev Biochem. 2018 Jun 20;87:263-294. doi: 10.1146/annurev-biochem-062917-012415. Epub 2018 Apr 25.
5
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6
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