在青蛙早期胚胎发育过程中，Xwnt-11信使核糖核酸从无活性形式向多核糖体的转变。

Transition of Xwnt-11 mRNA from inactive form to polyribosomes in frogs during early embryogenesis.

作者信息

Shatilov D V, Pshennikova E S, Voronina A S

机构信息

Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia.

出版信息

Biochemistry (Mosc). 2003 Jul;68(7):822-5. doi: 10.1023/a:1025099320362.

DOI:10.1023/a:1025099320362

PMID:12946266

Abstract

The distribution of Xwnt-11 mRNA between polysomes and informosomes was studied in Xenopus laevis and Rana temporaria during early embryogenesis. The ratio between polysomes and informosomes suggests their involvement in translation of these mRNAs. In eggs and immediately after fertilization the Xwnt-11 mRNAs are mostly positioned in informosomes. During the cleavage stage, these mRNAs have also been recognized in polysomes. Just before the onset of zygote genome functioning (at the stage of mid blastula), Xwnt-11 mRNA rapidly appears in polysomes of Rana embryos. However, in Xenopus, Xwnt-11 mRNA appears in polysomes only at the end of gastrula. Before this stage, the Xwnt-11 mRNA in Xenopus can be found mostly in informosomes.

摘要

在非洲爪蟾和欧洲林蛙的早期胚胎发育过程中，研究了Xwnt - 11 mRNA在多核糖体和信息体之间的分布情况。多核糖体与信息体之间的比例表明它们参与了这些mRNA的翻译过程。在卵子以及受精后即刻，Xwnt - 11 mRNA大多定位于信息体中。在卵裂阶段，这些mRNA也在多核糖体中被识别出来。就在合子基因组开始发挥功能之前（在囊胚中期阶段），Xwnt - 11 mRNA迅速出现在欧洲林蛙胚胎的多核糖体中。然而，在非洲爪蟾中，Xwnt - 11 mRNA仅在原肠胚末期出现在多核糖体中。在此阶段之前，非洲爪蟾中的Xwnt - 11 mRNA大多可在信息体中找到。