MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but not accuracy in learning the Hebb-Williams Maze.

We compared spatial learning and memory in male and female mice of two MHC-congenic strains (C57BL/6J and B6-H-2K) in two versions of the Hebb-Williams Maze. In the food-reward paradigm, males required fewer sessions to learn than females, but there were no strain differences in acquisition. There were no strain or sex differences in the number of errors during the test phase, but the B6-H-2K mice reached the goal box faster than the C57BL/6J mice. In the water-escape paradigm, the C57BL/6J mice required more sessions than the B6-H-2K mice during acquisition. There were no strain or sex differences in the number of errors or in the latency to swim to the goal box in the test phase of the water-escape task. There were no significant correlations between the number of sessions to learn the two mazes; the number of errors made or the latencies to reach the goal box in each maze. These results indicate that these two strains show differences in performance in the Hebb-Williams Maze, but do not differ in cognitive ability.