Kasuga I, Paré P D, Ruan J, Connett J E, Anthonisen N R, Sandford A J
University of British Columbia, McDonald Research Laboratories/iCAPTURE Center, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.
Thorax. 2003 Sep;58(9):790-3. doi: 10.1136/thorax.58.9.790.
Airway inflammation may affect the decrease in lung function that occurs in response to cigarette smoke, and is an important pathological feature in chronic obstructive pulmonary disease (COPD). Group specific component (GC) can act as an inflammatory mediator and may therefore have important influences on the inflammatory reaction in the airway. Several reports have described associations between GC haplotypes and COPD but these remain controversial. In addition, most of these studies were based on a small number of subjects.
We have studied the contribution of GC haplotypes to the level of lung function in a large cohort of smokers with high or low lung function (mean FEV(1) % predicted 91.8 and 62.6, respectively). The frequency of the three major GC haplotypes (1S, 1F and 2) was investigated in 537 individuals with high lung function and 533 with low lung function.
No significant difference was found in the frequency of any GC haplotype between the high and low lung function groups. There was also no significant difference between the groups in genotype frequency of the two single nucleotide polymorphisms that underlie the haplotypes.
The GC haplotype does not contribute to reduced lung function in this cohort of smokers.
气道炎症可能影响因接触香烟烟雾而发生的肺功能下降，并且是慢性阻塞性肺疾病（COPD）的一个重要病理特征。类特异性成分（GC）可作为一种炎症介质，因此可能对气道中的炎症反应产生重要影响。有几份报告描述了GC单倍型与COPD之间的关联，但这些关联仍存在争议。此外，这些研究大多基于少数受试者。
我们研究了GC单倍型对一大群肺功能高或低的吸烟者（预计平均第一秒用力呼气容积（FEV₁）百分比分别为91.8和62.6）肺功能水平的影响。在537名肺功能高的个体和533名肺功能低的个体中调查了三种主要GC单倍型（1S、1F和2）的频率。
肺功能高和低的两组之间，任何GC单倍型的频率均未发现显著差异。构成单倍型的两个单核苷酸多态性的基因型频率在两组之间也没有显著差异。
在这群吸烟者中，GC单倍型对肺功能降低没有影响。
