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白细胞介素-1β和白细胞介素-1受体拮抗剂单倍型与吸烟者肺功能下降速率的关联

Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.

作者信息

Joos L, McIntyre L, Ruan J, Connett J E, Anthonisen N R, Weir T D, Paré P D, Sandford A J

机构信息

UBC McDonald Research Laboratories/iCAPTURE Center, St Paul's Hospital, Vancouver, BC, Canada V6Z 1Y6.

出版信息

Thorax. 2001 Nov;56(11):863-6. doi: 10.1136/thorax.56.11.863.

DOI:10.1136/thorax.56.11.863
PMID:11641511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1745962/
Abstract

BACKGROUND

There is increasing evidence that the cytokine network is central to the immunopathology of inflammatory airway diseases. The interleukin 1 (IL-1) receptor antagonist (IL-1RN) is a naturally occurring anti-inflammatory agent that binds to the IL-1 receptor but does not possess agonist activity. Each of the genes of the IL-1 locus on chromosome 2q14 is polymorphic. The IL1RN gene contains an 86 bp tandem repeat and allele 2 of this polymorphism has been associated with various inflammatory diseases. The IL-1beta (IL1B) gene contains a promoter polymorphism (C-511T) that has been associated with inflammatory diseases and is in linkage disequilibrium with the IL1RN polymorphism.

METHODS

We investigated whether polymorphisms in the IL1B and IL1RN genes were associated with rate of decline of lung function. Genotypes were determined in 284 smokers with a rapid decline in lung function and 306 smokers with no decline in lung function.

RESULTS

None of the genotypes was associated with the rate of decline of lung function. However, the distribution of IL1B/IL1RN haplotypes was different between smokers with a rapid decline in lung function and those with no decline in lung function (p=0.0005).

CONCLUSION

These results suggest that IL1B/IL1RN haplotypes play a role in the rate of decline in lung function in smokers.

摘要

背景

越来越多的证据表明，细胞因子网络在炎症性气道疾病的免疫病理学中起核心作用。白细胞介素1（IL-1）受体拮抗剂（IL-1RN）是一种天然存在的抗炎剂，它与IL-1受体结合但不具有激动剂活性。位于2q14染色体上的IL-1基因座的每个基因都是多态性的。IL1RN基因包含一个86 bp的串联重复序列，该多态性的等位基因2与多种炎症性疾病有关。IL-1β（IL1B）基因包含一个启动子多态性（C-511T），它与炎症性疾病有关，并且与IL1RN多态性处于连锁不平衡状态。

方法

我们研究了IL1B和IL1RN基因的多态性是否与肺功能下降速率相关。对284名肺功能快速下降的吸烟者和306名肺功能未下降的吸烟者进行了基因型测定。

结果

没有一种基因型与肺功能下降速率相关。然而，肺功能快速下降的吸烟者和肺功能未下降的吸烟者之间，IL1B/IL1RN单倍型的分布有所不同（p = 0.0005）。

结论

这些结果表明，IL1B/IL1RN单倍型在吸烟者肺功能下降速率中起作用。

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本文引用的文献

1
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Biochem Biophys Res Commun. 2000 Sep 24;276(2):607-12. doi: 10.1006/bbrc.2000.3516.
2
Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD.
Respir Med. 2000 Sep;94(9):847-51. doi: 10.1053/rmed.2000.0808.
3
Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms.
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):755-8. doi: 10.1164/ajrccm.162.2.9909053.
4
Differences in the genotypes and plasma concentrations of the INTERLEUKIN-1 receptor antagonist in black and white South African asthmatics and control subjects.
Cytokine. 2000 Jun;12(6):819-21. doi: 10.1006/cyto.1999.0637.
5
Genetic polymorphisms of interleukin-1beta in association with the development of alcoholic liver disease in Japanese patients.
Am J Gastroenterol. 2000 May;95(5):1305-11. doi: 10.1111/j.1572-0241.2000.02030.x.
6
Influence of interleukin-1beta gene polymorphisms on age-at-onset of sporadic Parkinson's disease.
Neurosci Lett. 2000 Apr 21;284(1-2):73-6. doi: 10.1016/s0304-3940(00)00991-5.
7
Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis.
J Neuroimmunol. 2000 Jun 1;105(1):96-101. doi: 10.1016/s0165-5728(00)00203-4.
8
Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis.
Gastroenterology. 1999 Oct;117(4):806-13. doi: 10.1016/s0016-5085(99)70338-0.
9
IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease.
Immunogenetics. 1999 Jun;49(6):527-31. doi: 10.1007/s002510050530.
10
IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes.
Eur J Immunol. 1998 Aug;28(8):2598-602. doi: 10.1002/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K.

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