Merceron-Saffon Nathalie, Baceiredo Antoine, Gornitzka Heinz, Bertrand Guy
Laboratoire Hétérochimie Fondamentale et Appliquée [Unité Mixte de Recherche (UMR) 5069], Université Paul Sabatier, 118, route de Narbonne, F-31062 Toulouse Cedex 04, France.
Science. 2003 Aug 29;301(5637):1223-5. doi: 10.1126/science.1086860.
An (amino)(phosphino) carbene can be transformed into (amino)(phosphonio) carbenes, which undergo nucleophilic intermolecular as well as intramolecular substitution reactions at the carbene center. A variety of carbenes can be synthesized starting from a single carbene precursor. The resulting gamut of electronic and steric effects possible should open the way not only to a detailed study of the mechanism, but also to the subsequent improvement of catalytic reactions that involve carbene-transition metal complexes.
（氨基）（膦基）卡宾可以转化为（氨基）（鏻基）卡宾，后者在卡宾中心发生亲核分子间以及分子内取代反应。从单一卡宾前体出发可以合成多种卡宾。由此可能产生的一系列电子效应和空间效应不仅应为详细研究反应机理开辟道路，也应为后续改进涉及卡宾 - 过渡金属配合物的催化反应创造条件。
