Pincus T, Marcum S B, Callahan L F, Adams R F, Barber J, Barth W F, Gordon G V, Huston J W, Polk J R, Whelton J C
Department of Medicine, Vanderbilt University, Nashville, TN 37232.
J Rheumatol. 1992 Dec;19(12):1874-84.
The probability of continuation of a particular nonsteroidal antiinflammatory drug (NSAID) over 5 years was estimated for 1,775 courses taken by 532 patients with rheumatoid arthritis treated in 7 rheumatology private practices. Similar results were seen for 15 different NSAID--48% of courses were continued at 12 months, 36% at 24 months, and 20% at 60 months. Only acetylated salicylates, other than plain aspirin, were continued significantly longer than any of the other NSAID. The probability of continuation of plain aspirin was similar to other NSAID, including nonacetylated salicylates and nonsalicylate NSAID. The first NSAID taken by an individual patient was continued only marginally longer than the 4th NSAID taken by the same patient. While most NSAID courses were not continued for long periods, 20% were continued for longer than 5 years, suggesting effective longterm results in this minority of courses.
在7家私人风湿病诊所接受治疗的532名类风湿性关节炎患者服用了1775个疗程的特定非甾体抗炎药（NSAID），对其持续使用5年的概率进行了评估。15种不同的NSAID呈现出相似的结果——48%的疗程在12个月时仍在继续，36%在24个月时仍在继续，20%在60个月时仍在继续。除普通阿司匹林外，只有乙酰化水杨酸盐的持续使用时间明显长于其他任何一种NSAID。普通阿司匹林的持续使用概率与其他NSAID相似，包括非乙酰化水杨酸盐和非水杨酸盐类NSAID。个体患者服用的第一种NSAID的持续使用时间仅比该患者服用的第4种NSAID略长。虽然大多数NSAID疗程不会持续很长时间，但20%的疗程持续时间超过了5年，这表明在这少数疗程中取得了有效的长期效果。
