Okada M, Yoshioka K, Isokawa S, Takemura T, Kinoshita T, Akano N, Maki S
Department of Pediatrics, Kinki University School of Medicine.
Nihon Jinzo Gakkai Shi. 1992 Nov;34(11):1195-9.
This paper describes a case report of acute interstitial nephritis associated with Bufferin. A 15-year-old girl were referred to our hospital due to fever and renal dysfunction. Laboratory findings showed elevation of serum BUN and creatinine, and increased urinary beta 2-MG excreation. Light microscopic findings of her renal biopsy specimen revealed edema and numerous inflammatory cells in the interstitium, and minor alterations in glomeruli. The interstitial infiltrates consisted mainly of T cells and also monocytes/macrophages. Interstitial cells were labelled with antibodies to interleukin (IL)-1 and tumor necrose factor (TNF). Bufferin was positive by lymphocyte stimulation test. Thus, we considered that this drug was causative in this case. This observation suggests the participation of cell-mediated immune injury in drug induced acute interstitial nephritis.
本文描述了一例与百服宁相关的急性间质性肾炎病例报告。一名15岁女孩因发热和肾功能不全被转诊至我院。实验室检查结果显示血清尿素氮和肌酐升高，尿β2-微球蛋白排泄增加。其肾活检标本的光镜检查结果显示间质水肿和大量炎性细胞，肾小球有轻微改变。间质浸润主要由T细胞以及单核细胞/巨噬细胞组成。间质细胞用白细胞介素（IL）-1和肿瘤坏死因子（TNF）抗体标记。淋巴细胞刺激试验显示百服宁呈阳性。因此，我们认为该药物是此病例的病因。这一观察结果提示细胞介导的免疫损伤参与了药物性急性间质性肾炎。
