Tadic Mario, Grgurevic Ivica, Scukanec-Spoljar Mira, Bozic Borka, Marusic Srecko, Horvatic Ivica, Galesic Kresimir
Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia.
Nephrology (Carlton). 2005 Apr;10(2):103-5. doi: 10.1111/j.1440-1797.2005.00376.x.
A case of mesalazine-induced acute interstitial nephritis (AIN) in a 41-year-old patient with ulcerative colitis (UC) is reported here. Clinical symptoms such as fever and arthralgia, and laboratory findings such as eosinophilia and renal failure suggested AIN, which was confirmed by biopsy. With withdrawal of mesalazine and intravenous methylprednisolone the patient's renal function was recovered. It is observed that early discontinuation of mesalazine is associated with amelioration of interstitial nephritis in most patients, so the recommendation is that patients receiving mesalazine should undergo routine monitoring of renal function. Delayed diagnosis may lead to permanent renal function impairment.
本文报告了1例41岁溃疡性结肠炎（UC）患者因美沙拉嗪诱发急性间质性肾炎（AIN）的病例。发热、关节痛等临床症状以及嗜酸性粒细胞增多和肾衰竭等实验室检查结果提示为AIN，活检证实了这一诊断。停用美沙拉嗪并静脉注射甲泼尼龙后，患者肾功能恢复。观察发现，大多数患者早期停用美沙拉嗪与间质性肾炎改善相关，因此建议接受美沙拉嗪治疗的患者应定期监测肾功能。延迟诊断可能导致永久性肾功能损害。
