Stinchcomb Audra L
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Lexington, Kentucky 40536-0082, USA.
Pharm Res. 2003 Aug;20(8):1113-8. doi: 10.1023/a:1025024309223.
There is a great need for alternative experimental methods for measuring percutaneous xenobiotic biotransformation. Animal testing and excised human skin studies have been the historical standards for confirmation of therapeutic and toxic effects that occur in the skin as a result of drug and other chemical metabolism. Human skin epidermal bioequivalents have become progressively more used for these types of pharmacological/toxicological studies in recent years. These epidermal models have been used in the form of cell culture, tissue sheets, and highly differentiated epidermal and epidermal/dermal systems. This review highlights the existing published data on the utility of these skin bioequivalent models for various types of metabolism and toxicology studies that should be of interest to the dermatopharmaceutical scientist.
迫切需要用于测量经皮外源性生物转化的替代实验方法。动物试验和切除人体皮肤研究一直是确认药物和其他化学物质代谢在皮肤中产生的治疗和毒性作用的历史标准。近年来，人皮肤表皮生物等效物越来越多地用于这类药理/毒理学研究。这些表皮模型已以细胞培养、组织片以及高度分化的表皮和表皮/真皮系统的形式得到应用。本综述重点介绍了这些皮肤生物等效模型在各种代谢和毒理学研究中的现有已发表数据，这些数据应该会引起皮肤药物科学家的兴趣。
