Wang Hai-Xia, Chen Qi-Kui
Department of Gastroenterology,The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Ai Zheng. 2003 Jun;22(6):649-52.
BACKGROUND & OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) reduced the incidence of gastrointestinal neoplasms with inhibition of cyclooxygenase-2 (COX-2). This study was designed to investigate the expression and significance of COX-2 and the relationship between COX-2 and bcl-2 in human pancreatic carcinoma.
COX-2 and bcl-2 expression was determined with ABC immunohistochemical analysis in the samples of pancreatic carcinoma.
COX-2 and bcl-2 proteins were found in 22 of 30 (73.3%) and 20 of 30 (66.7%) patients with pancreatic carcinoma, which were higher than those with pancreatic benign disease and normal pancreas,respectively (P< 0.05). There was positive correlation between the expression rates of COX-2 and bcl-2 in pancreatic carcinoma. The correlation coefficient was 0.470 (P< 0.01). There was no significant difference in expression rates of COX-2 in patients among age, sex, tumor location, tumor size, histological degree, and TNM staging (P >0.05).
COX-2 protein is overexpressed in human pancreatic carcinoma. The co-expression of COX-2 and bcl-2 might play an important role in the regulation of apoptosis of pancreatic carcinoma cells.
非甾体抗炎药（NSAIDs）通过抑制环氧化酶-2（COX-2）降低胃肠道肿瘤的发生率。本研究旨在探讨COX-2在人胰腺癌中的表达及意义，以及COX-2与bcl-2的关系。
采用ABC免疫组化分析法检测胰腺癌组织样本中COX-2和bcl-2的表达。
30例胰腺癌患者中，22例（73.3%）检测到COX-2蛋白，20例（66.7%）检测到bcl-2蛋白，二者表达水平均分别高于胰腺良性疾病患者和正常胰腺组织（P<0.05）。胰腺癌中COX-2与bcl-2的表达率呈正相关，相关系数为0.470（P<0.01）。COX-2在患者中的表达率在年龄、性别、肿瘤部位、肿瘤大小、组织学分级和TNM分期方面无显著差异（P>0.05）。
COX-2蛋白在人胰腺癌中过度表达。COX-2与bcl-2的共同表达可能在胰腺癌细胞凋亡调控中起重要作用。
