血管内皮生长因子、环氧合酶-2及Bcl-2在卵巢交界性肿瘤中的表达及临床意义

Expression and clinical significance of vascular endothelial growth factor, cyclooxygenase-2, and Bcl-2 in borderline ovarian tumors.

作者信息

Li Min, Qi Shu-Ying, Wang Yong, Feng Shu-Xian, Zhang Bang-Zhi, Wang Rui

机构信息

Department of Pathology, Lanzhou Medical College, Lanzhou University, Gansu Province, 730000, People's Republic of China.

出版信息

Arch Gynecol Obstet. 2005 Jun;272(1):48-52. doi: 10.1007/s00404-004-0708-9. Epub 2005 Jan 29.

DOI:10.1007/s00404-004-0708-9

PMID:15682318

Abstract

OBJECTIVE

The objectives were to study the expression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (Cox-2), and Bcl-2 in borderline ovarian tumors (BOTs) and the relationship within them, and to investigate the correlation between expression of VEGF, Cox-2, and Bcl-2, and the clinicopathologic features of BOTs.

METHODS

An immunohistochemical technique was used to investigate the expression of VEGF ,Cox-2, and Bcl-2 in 69 borderline, 18 benign, and 27 malignant human ovarian tumor tissues.

RESULTS

Expression rate of VEGF protein (59.4%) in BOTs was higher than in benign tumors (27.8%) and was lower than in ovarian carcinomas (92.6%), and there was a significant difference between BOTs and benign ovarian tumors (p < 0.05), and carcinoma (p < 0.01). Significant correlation was observed between the positive expression rate for VEGF and clinical stage of BOTs (p < 0.05). The statistical analysis did not show a close correlation between the expression of VEGF and tissue type, and peritoneal implants in BOTs (p > 0.05). The expression rate of Cox-2 was significantly higher in ovarian carcinomas (81.5%) than in BOTs (57.9%) and in benign ovarian tumors (38.9%) (p < 0.05). Significant correlation was observed between the positive expression rate for Cox-2 and the clinical stage of BOTs (p < 0.05). The statistical analysis showed no close correlation between the expression of Cox-2 and tissue type, and peritoneal implants in BOTs (p > 0.05). There was a significant difference between the expression of Bcl-2 in ovarian carcinomas and BOTs than that in benign ovarian tumors (p < 0.05). The positive expression rate of Bcl-2 was not related to clinical stages and peritoneal implants (p > 0.05). Statistical analysis showed a positive correlation between the expression of Cox-2 and VEGF, and Bcl-2 in BOTs.

CONCLUSIONS

Overexpression of VEGF, Cox-2, and Bcl-2 in BOTs may play an important role in the oncogenesis and progression of BOTs. It is feasible to detect VEGF, Cox-2, and Bcl-2 in the diagnosis and to predict the prognosis of BOTs.

摘要

目的

研究血管内皮生长因子（VEGF）、环氧合酶-2（Cox-2）和Bcl-2在卵巢交界性肿瘤（BOTs）中的表达及其相互关系，并探讨VEGF、Cox-2和Bcl-2的表达与BOTs临床病理特征之间的相关性。

方法

采用免疫组织化学技术检测69例人卵巢交界性肿瘤、18例良性肿瘤及27例恶性肿瘤组织中VEGF、Cox-2和Bcl-2的表达。

结果

BOTs中VEGF蛋白表达率（59.4%）高于良性肿瘤（27.8%），低于卵巢癌（92.6%），BOTs与良性卵巢肿瘤之间差异有统计学意义（p<0.05），与癌之间差异有高度统计学意义（p<0.01）。VEGF阳性表达率与BOTs临床分期之间存在显著相关性（p<0.05）。统计学分析显示VEGF表达与BOTs组织类型及腹膜种植之间无密切相关性（p>0.05）。卵巢癌中Cox-2表达率（81.5%）显著高于BOTs（57.9%）和良性卵巢肿瘤（38.9%）（p<0.05）。Cox-2阳性表达率与BOTs临床分期之间存在显著相关性（p<0.05）。统计学分析显示Cox-2表达与BOTs组织类型及腹膜种植之间无密切相关性（p>0.05）。卵巢癌与BOTs中Bcl-2的表达与良性卵巢肿瘤之间存在显著差异（p<0.05）。Bcl-2阳性表达率与临床分期及腹膜种植无关（p>0.05）。统计学分析显示BOTs中Cox-2与VEGF、Bcl-2的表达呈正相关。