转化生长因子β在心血管发育与功能中的作用
Transforming growth factor beta in cardiovascular development and function.
作者信息
Azhar Mohamad, Schultz Jo El J, Grupp Ingrid, Dorn Gerald W, Meneton Pierre, Molin Daniel G M, Gittenberger-de Groot Adriana C, Doetschman Thomas
机构信息
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
出版信息
Cytokine Growth Factor Rev. 2003 Oct;14(5):391-407. doi: 10.1016/s1359-6101(03)00044-3.
Abstract
Transforming growth factor betas (TGFbetas) are pleiotropic cytokines involved in many biological processes. Genetic engineering and tissue explanation studies have revealed specific non-overlapping roles for TGFbeta ligands and their signaling molecules in development and in normal function of the cardiovascular system in the adult. In the embryo, TGFbetas appear to be involved in epithelial-mesenchymal transformations (EMT) during endocardial cushion formation, and in epicardial epithelial-mesenchymal transformations essential for coronary vasculature, ventricular myocardial development and compaction. In the adult, TGFbetas are involved in cardiac hypertrophy, vascular remodeling and regulation of the renal renin-angiotensin system. The evidence for TGFbeta activities during cardiovascular development and physiologic function will be given and areas which need further investigation will be discussed.
摘要
转化生长因子β（TGFβ）是参与多种生物学过程的多效性细胞因子。基因工程和组织学解释研究已经揭示了TGFβ配体及其信号分子在发育过程以及成人心血管系统正常功能中的特定非重叠作用。在胚胎中，TGFβ似乎参与心内膜垫形成过程中的上皮-间充质转化（EMT），以及对冠状动脉血管、心室心肌发育和致密化至关重要的心外膜上皮-间充质转化。在成体中，TGFβ参与心脏肥大、血管重塑以及肾脏肾素-血管紧张素系统的调节。将给出TGFβ在心血管发育和生理功能过程中活性的证据，并讨论需要进一步研究的领域。
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