Marsh Derek, Bartucci Rosa, Sportelli Luigi
Max-Planck-Institut für Biophysikalische Chemie, Abteilung Spektroskopie, Am Fassberg 11, D-37077 Göttingen, Germany.
Biochim Biophys Acta. 2003 Sep 2;1615(1-2):33-59. doi: 10.1016/s0005-2736(03)00197-4.
Membranes grafted with water-soluble polymers resist protein adsorption and adhesion to cellular surfaces. Liposomes with surface-grafted polymers therefore find applications in drug delivery. The physicochemical properties of polymer-grafted lipid membranes are reviewed with mean-field and scaling theories from polymer physics. Topics covered are: mushroom-brush transitions, membrane expansion and elasticity, bilayer-micelle transitions, membrane-membrane interactions and protein-membrane interactions.
接枝水溶性聚合物的膜可抵抗蛋白质吸附并防止其粘附于细胞表面。因此，表面接枝聚合物的脂质体在药物递送中得到应用。本文运用高分子物理学中的平均场理论和标度理论，综述了聚合物接枝脂质膜的物理化学性质。涵盖的主题包括：蘑菇-刷状转变、膜的膨胀与弹性、双层-胶束转变、膜-膜相互作用以及蛋白质-膜相互作用。
