Toulouse Pierre, Agulhon Cyril, Taussig Delphine, Napuri Sylvia, Biraben Arnaud, Jannin Pierre, Carsin Michel, Scarabin Jean-Marie
Laboratoire de Physiologie-Explorations Fonctionnelles, Université de Rennes I, CHU Rennes, Rue Henri Le Guilloux, 35033 Rennes Cedex, France.
Neuroimage. 2003 Aug;19(4):1251-9. doi: 10.1016/s1053-8119(03)00173-3.
Two cases (a young male and a girl, suffering intractable epilepsy) of diffuse subcortical laminar heterotopia, or so-called double cortex (DC) have been investigated using magnetoencephalography (MEG). MEG confirmed involvement of both cortices (hetero- and normocortex) in the genesis of interictal spikes, and, according to the heterogeneity of DC syndrome, some differences were observed: spike initiation in the normocortex and latter involvement of the heterotopic cortex in the man, and rather a cancellation in both cortices in the girl. In addition, participation of heterotopic cortex in physiological activities could be demonstrated in the man.
我们使用脑磁图（MEG）对两例弥漫性皮质下板层异位症（即所谓的双皮质综合征，DC）患者（一名年轻男性和一名女孩，均患有难治性癫痫）进行了研究。脑磁图证实发作间期棘波的产生涉及到两个皮质（异位皮质和正常皮质），并且根据双皮质综合征的异质性，观察到了一些差异：在男性患者中，棘波起始于正常皮质，随后异位皮质也参与其中；而在女孩中，两个皮质的棘波活动则有所抵消。此外，在男性患者中还证实了异位皮质参与了生理活动。
