Olszewski Pawel K, Grace Martha K, Billington Charles J, Levine Allen S
Veterans Affairs Medical Center, 1 Veterans Drive, Research Route 151, Minneapolis, MN 55417, USA.
Peptides. 2003 Jun;24(6):919-23. doi: 10.1016/s0196-9781(03)00159-1.
The paraventricular hypothalamic nucleus (PVN) appears to integrate orexigenic properties of a novel peptide, ghrelin. Thus, we examined central mechanisms underlying feeding generated by intra-PVN ghrelin. We established that 0.03 nmol of PVN-injected ghrelin was the lowest dose increasing food consumption and it induced c-Fos immunoreactivity (a marker of neuronal activation) in the PVN itself, as well as in other feeding-related brain areas, including the hypothalamic arcuate and dorsomedial nuclei, central nucleus of the amygdala, and nucleus of the solitary tract. We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin.
下丘脑室旁核（PVN）似乎整合了一种新型肽——胃饥饿素的促食欲特性。因此，我们研究了PVN内注射胃饥饿素引发进食的中枢机制。我们确定，注射到PVN的0.03 nmol胃饥饿素是增加食物摄入量的最低剂量，它能诱导PVN本身以及其他与进食相关的脑区（包括下丘脑弓状核和背内侧核、杏仁核中央核以及孤束核）产生c-Fos免疫反应性（神经元激活的标志物）。我们得出结论，作为更大的中枢神经回路的一部分，PVN介导了胃饥饿素的促食欲特性。
