Ruzicka Thomas, Assmann Till, Lebwohl Mark
Department of Dermatology, University of Düsseldorf, Moorenstr 5, 40225 Düsseldorf, Germsny.
Eur J Dermatol. 2003 Jul-Aug;13(4):331-42.
Tacrolimus ointment is a steroid-free topical immunomodulator developed for the treatment of atopic dermatitis, a common, chronic inflammatory skin disease. By inhibiting T-cell activation and cytokine production, topically applied tacrolimus modulates inflammatory responses in the skin. Numerous clinical trials have shown that it is effective and well tolerated for the treatment of atopic dermatitis, its licensed indication. In addition, numerous publications suggest that tacrolimus ointment may provide effective treatment for a variety of other inflammatory skin disorders, many of which are very difficult to manage with standard therapy. This paper reviews currently available evidence regarding the use of tacrolimus ointment in a range of dermatological disorders, including psoriasis, lichen planus, pyoderma gangrenosum, lichen sclerosus, contact dermatitis, leg ulcers in rheumatoid arthritis, steroid-induced rosacea and alopecia areata. It also provides recommendations for future clinical studies with tacrolimus ointment.
他克莫司软膏是一种不含类固醇的局部免疫调节剂，用于治疗特应性皮炎，这是一种常见的慢性炎症性皮肤病。通过抑制T细胞活化和细胞因子产生，局部应用他克莫司可调节皮肤中的炎症反应。大量临床试验表明，它对特应性皮炎（其获批适应症）的治疗有效且耐受性良好。此外，众多出版物表明，他克莫司软膏可能为多种其他炎症性皮肤病提供有效治疗，其中许多疾病用标准疗法很难治疗。本文综述了目前关于他克莫司软膏在一系列皮肤病中的应用的现有证据，包括银屑病、扁平苔藓、坏疽性脓皮病、硬化性苔藓、接触性皮炎、类风湿性关节炎患者的腿部溃疡、类固醇性酒渣鼻和斑秃。它还为未来使用他克莫司软膏的临床研究提供了建议。
