皮肤和舌部丘疹作为长期血液透析患者β2微球蛋白源性淀粉样变性的体征
Cutaneous and lingual papules as a sign of beta 2 microglobulin-derived amyloidosis in a long-term hemodialysis patient.
作者信息
Uenotsuchi Takeshi, Imafuku Shinichi, Nagata Masaharu, Kiryu Hiromaro, Morita Keisuke, Koga Tetsuya, Furue Masutaka
机构信息
Department of Dermatology, Hiroshima Red Cross Hospital, Hiroshima, Japan.
出版信息
Eur J Dermatol. 2003 Jul-Aug;13(4):393-5.
Although hemodialysis has permitted long-term survival of patients with renal failure, beta 2 microglobulin-derived amyloidosis is a serious complication occurring most commonly in long-term hemodialysis patients. Orthopedic manifestations are quite common, but cutaneous and lingual manifestations are relatively uncommon. We report a 56-year-old patient with lichenoid plaque type of skin eruptions and lingual papules caused by beta 2 microglobulin-derived amyloidosis. Immunohistochemical study showed that amyloid deposits were positive for anti-beta 2 microglobulin antibody, but negative for anti-advanced glycation end products antibody (anti-CML and CLE antibody). We discuss the histological and the clinical features of skin manifestations of beta 2 microglobulin-derived amyloidosis.
尽管血液透析已使肾衰竭患者长期存活，但β2微球蛋白衍生的淀粉样变性是一种严重并发症，最常发生于长期血液透析患者。骨科表现相当常见，但皮肤和舌部表现相对少见。我们报告一例56岁患者，其皮肤出现苔藓样斑块型皮疹，舌部出现丘疹，由β2微球蛋白衍生的淀粉样变性引起。免疫组织化学研究显示，淀粉样沉积物对抗β2微球蛋白抗体呈阳性，但对抗晚期糖基化终产物抗体（抗CML和CLE抗体）呈阴性。我们讨论了β2微球蛋白衍生的淀粉样变性皮肤表现的组织学和临床特征。
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