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[神经外科重症治疗中潜在器官捐献者的治疗与结局。一项为期3年的分析]

[Treatment and outcome of prospective organ donors in neurosurgical intensive therapy. Analysis of a 3-year period].

作者信息

Simini G, Mazzon D, Bosco E, Dal Ferro M, Miceli G B, Manuali A

出版信息

Minerva Anestesiol. 1992 Nov;58(11):1221-6.

PMID:1294903
Abstract

Strict guidelines for selection, monitoring and treatment of Potential Organ Donors (POD) in Neurosurgical Intensive Care Units (ICUs) are mandatory since patients with Acute Brain Injuries (ABI) are more frequently admitted on these specialized ICUs. We report the guidelines accepted in the Neurosurgical ICU of Treviso City Hospital (TVH) and the results obtained in the last three years (1988-1990). All patients with unfavourable neurological outcome were considered POD if absolute or relative contraindications to organ procurement were absent. They were treated with a multisystemic approach, according to standard protocols, including: ECG monitoring, water and electrolyte balance restoration, pharmacological cardiocirculatory support, prophylaxis and treatment of infections, control of hormonal disturbances. Our data demonstrate an increase of POD from TVH due to the centralization of patients with ABI in the Neurosurgical ICU and show an increase of the rate of POD from Neurosurgical ICU vs General ICU of TVH. The increase of POD in the Neurosurgical ICUs involves medical, legal, organizing and psychological problems, related to this clinical condition. The attention to severe protocols, that must be periodically reviewed, makes more easy the management of POD and ameliorates the outcome of these patients.

摘要

由于急性脑损伤(ABI)患者更频繁地入住神经外科重症监护病房(ICU),因此制定严格的潜在器官捐献者(POD)选择、监测和治疗指南是必不可少的。我们报告了特雷维索市立医院(TVH)神经外科ICU所采用的指南以及过去三年(1988 - 1990年)所取得的成果。如果不存在器官获取的绝对或相对禁忌证,所有神经功能预后不良的患者均被视为POD。按照标准方案,采用多系统方法对他们进行治疗,包括:心电图监测、恢复水和电解质平衡、药物性心脏循环支持、预防和治疗感染、控制激素紊乱。我们的数据表明,由于ABI患者集中在神经外科ICU,TVH的POD数量有所增加,并且与TVH的普通ICU相比,神经外科ICU的POD比率有所上升。神经外科ICU中POD数量的增加涉及到与这种临床状况相关的医学、法律、组织和心理问题。对必须定期审查的严格方案的关注,使得POD的管理更加容易,并改善了这些患者的预后。

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