病毒感染过程中趋化因子的表达与功能：从分子机制到体内功能
Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function.
作者信息
Melchjorsen Jesper, Sørensen Louise N, Paludan Søren R
机构信息
Department of Medical Microbiology and Immunology, University of Aarhus, Denmark.
出版信息
J Leukoc Biol. 2003 Sep;74(3):331-43. doi: 10.1189/jlb.1102577.
Abstract
Recruitment and activation of leukocytes are important for elimination of microbes, including viruses, from infected areas. Chemokines constitute a group of bioactive peptides that regulate leukocyte migration and also contribute to activation of these cells. Chemokines are essential mediators of inflammation and important for control of viral infections. The profile of chemokine expression contributes to shaping the immune response during viral infection, whereas viral subversion of the chemokine system allows the virus to evade antiviral activities of the host. In this review, we discuss the role of chemokines in host-defense against virus infections, and we also look deeper into the virus-cell interactions that trigger chemokine expression as well as the cellular signaling cascades involved.
摘要
白细胞的募集和激活对于从感染区域清除包括病毒在内的微生物至关重要。趋化因子是一类调节白细胞迁移并有助于激活这些细胞的生物活性肽。趋化因子是炎症的重要介质，对控制病毒感染也很重要。趋化因子表达谱有助于在病毒感染期间塑造免疫反应，而趋化因子系统的病毒颠覆则使病毒能够逃避宿主的抗病毒活性。在本综述中，我们讨论了趋化因子在宿主抵御病毒感染中的作用，并且我们还更深入地研究了触发趋化因子表达的病毒-细胞相互作用以及所涉及的细胞信号级联反应。
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