Porter B F, Frost P, Hubbard G B
Southwest National Primate Research Center/Southwest Foundation for Biomedical Research, P. O. Box 760549, San Antonio, TX 78245-0549, USA.
Vet Pathol. 2003 Sep;40(5):570-3. doi: 10.1354/vp.40-5-570.
Polyarteritis nodosa (PAN) is an idiopathic necrotizing vasculitis affecting small- to medium-sized arteries. The disease is well recognized in humans, and PAN-like syndromes have been described in a number of other species. This report describes a case of PAN in a 6-year-old male cynomolgus macaque. The animal had necrotizing arteritis affecting vessels in the kidney, small intestine, colon, heart, spleen, mesentery, urinary bladder, and pancreas. The lesions were segmental in distribution and of varying severity and stage of development. A transmural mixed inflammatory cell infiltrate was present, often accompanied by fibrinoid necrosis of the tunica media and loss of the internal elastic lamina. Immunohistochemical staining showed that many of the infiltrating cells were T lymphocytes and histiocytes, suggesting a cell-mediated component to the pathogenesis.
结节性多动脉炎（PAN）是一种影响中小动脉的特发性坏死性血管炎。该疾病在人类中已得到充分认识，并且在许多其他物种中也描述了类似PAN的综合征。本报告描述了一例6岁雄性食蟹猴的PAN病例。该动物患有坏死性动脉炎，累及肾脏、小肠、结肠、心脏、脾脏、肠系膜、膀胱和胰腺中的血管。病变呈节段性分布，严重程度和发展阶段各不相同。存在透壁混合性炎性细胞浸润，常伴有中膜纤维蛋白样坏死和内弹力层丧失。免疫组织化学染色显示，许多浸润细胞是T淋巴细胞和组织细胞，提示发病机制中有细胞介导的成分。
