Cichon Nicole, Lampe Karen, Bremmer Felix, Becker Tamara, Mätz-Rensing Kerstin
German Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Georg-August-Universität, Universitätsmedizin Göttingen, Robert Kochstr. 40, 37075 Göttingen, Germany.
Primate Biol. 2017 Apr 3;4(1):71-75. doi: 10.5194/pb-4-71-2017. eCollection 2017.
Overall, diseases of the vascular system are rarely observed entities among nonhuman primates that are commonly associated with systemic infections, septicemia or bacteremia. Rhesus monkeys infected with simian immunodeficiency virus (SIV) may develop a chronic occlusive arteriopathy of unknown etiology in late stages of the disease. This SIV associated arteriopathy is the only well-known specific vascular entity described in nonhuman primates. We herein report a unique case of granulomatous arteritis in a grey mouse lemur affecting multiple organs, which is not comparable to other disease entities formerly described in nonhuman primates. The features of the entity most closely resemble disseminated visceral giant cell arteritis in humans. A concise description of the disease is given, and the differential diagnoses are discussed. An idiopathic pathogenesis is suspected.
总体而言,在非人灵长类动物中,血管系统疾病是很少见的,通常与全身感染、败血症或菌血症有关。感染猿猴免疫缺陷病毒(SIV)的恒河猴在疾病后期可能会出现病因不明的慢性闭塞性动脉病。这种与SIV相关的动脉病是在非人灵长类动物中描述的唯一一种广为人知的特定血管疾病。我们在此报告一例灰鼠狐猴发生的累及多个器官的肉芽肿性动脉炎的独特病例,这与先前在非人灵长类动物中描述的其他疾病实体不同。该疾病实体的特征与人类的播散性内脏巨细胞动脉炎最为相似。本文给出了该疾病的简要描述,并讨论了鉴别诊断。怀疑其发病机制为特发性。