[不可逆排斥反应中人类同种异体肾移植浸润细胞原位产生γ干扰素和白细胞介素6。细胞因子的调节作用]
[In situ production of interferon gamma and interleukin 6 by infiltrating cells from human kidney allografts in irreversible rejection. Modulation by cytokines].
作者信息
Merville P, Pouteil-Noble C, Wijdenes J, Potaux L, Touraine J L, Banchereau J
机构信息
Schering-Plough, Dardilly.
出版信息
Presse Med. 1992 Dec 2;21(41):1966-7.
PMID:1294954
Abstract
Using ELISPOT assays, we detected a significant number of cells secreting interferon-gamma and interleukin 6 among 8 irreversibly rejected kidney allografts compared with normal kidneys. Interleukin 2 increases the frequency of interferon-gamma producing cells and interleukin 4 decreases the frequency of both interferon-gamma and interleukin 6 producing cells.
摘要
通过酶联免疫斑点分析（ELISPOT分析），我们发现在8个发生不可逆排斥反应的肾移植受者中，与正常肾脏相比，有大量细胞分泌干扰素-γ和白细胞介素6。白细胞介素2可增加产生干扰素-γ的细胞频率，而白细胞介素4可降低产生干扰素-γ和白细胞介素6的细胞频率。
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