Yoshida Kenichi
Genetic Diagnosis, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Cell Mol Biol Lett. 2003;8(3):735-41.
Protocadherins (Pcdhs) are a family of cadherins considered to play an important role in the cell-cell adhesion of specific neurons in the central nervous system. Of the reported Pcdhs, relatively little is known about the functional role of protocadherin 7 (Pcdh7), and there is no evidence of Pcdh7 mediated cell-cell adhesion. To date, three splicing variants are known; they may have different effects on cell phenotype. We report here that mouse fibroblast L cells stably overexpressing the Pcdh7 isoforms 7a and 7b, but not 7c, showed a morphological change and Ca(2+)dependent cell adhesion.
原钙黏蛋白（Pcdhs）是一类钙黏蛋白，被认为在中枢神经系统特定神经元的细胞间黏附中发挥重要作用。在已报道的原钙黏蛋白中，人们对原钙黏蛋白7（Pcdh7）的功能作用了解相对较少，且尚无Pcdh7介导细胞间黏附的证据。迄今为止，已知有三种剪接变体；它们可能对细胞表型有不同影响。我们在此报告，稳定过表达Pcdh7亚型7a和7b而非7c的小鼠成纤维细胞L细胞出现了形态变化和Ca(2+)依赖性细胞黏附。
