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强化乙醇制剂对大鼠酒精化过程中组织中生物源性单胺含量及乙醇代谢的影响。

Effect of preparations from potentiated ethanol on the content of biogenic monoamines and metabolism of ethanol in tissues of rats during alcoholization.

作者信息

Titkova A M, Epstein O I

机构信息

Institute of Neurology, Psychiatry, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.

出版信息

Bull Exp Biol Med. 2003 Jan;135 Suppl 7:36-8. doi: 10.1023/a:1024758108606.

Abstract

The effect of homeopathically potentiated ethanol (C30 and C200) on ethanol metabolism was studied in alcoholized rats. We measured ethanol concentration in the blood, alcohol dehydrogenase activity in the liver, and contents of biogenic monoamines in the hypothalamus, septum, and whole blood. Potentiated preparations of ethanol were efficient after long-term treatment and delayed ethanol elimination from the blood. Preparation C200 increased alcohol dehydrogenase activity. Potentiated preparations of ethanol (particularly C200) produced a positive effect on catecholaminergic and serotoninergic systems of the brain, i.e. they enhanced protective and adaptive reactions.

摘要

在酒精化大鼠中研究了顺势增强乙醇(C30和C200)对乙醇代谢的影响。我们测量了血液中的乙醇浓度、肝脏中的乙醇脱氢酶活性以及下丘脑、隔区和全血中生物源性单胺的含量。长期治疗后,增强的乙醇制剂有效且延迟了乙醇从血液中的清除。制剂C200增加了乙醇脱氢酶活性。增强的乙醇制剂(特别是C200)对大脑的儿茶酚胺能和血清素能系统产生了积极作用,即它们增强了保护和适应性反应。

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