长期强直后增强期间超低剂量抗体双相治疗的体外效应
In vitro effects of bipathic treatment with antibodies in ultralow doses during long-term post-tetanic potentiation.
作者信息
Epstein O I, Beregovoi N A, Pankova T M, Sorokina N S, Starostina M V, Shtark M B
机构信息
Materia Medica Holding Research-and-Production Company, Moscow.
出版信息
Bull Exp Biol Med. 2003 Jan;135 Suppl 7:111-3. doi: 10.1023/a:1024715821327.
PMID:12949670
Abstract
We studied the effects of individual or combination treatment with monoclonal antibodies 5F5-B6 in ultralow doses specifically marking mossy fibers in rat hippocampus and antibodies to S100 protein during long-term post-tetanic potentiation in hippocampal slices. The possible mechanisms of changes produced by therapeutic administration of antibodies in ultralow doses were revealed.
摘要
我们研究了超低剂量的单克隆抗体5F5 - B6（特异性标记大鼠海马苔藓纤维）与抗S100蛋白抗体联合或单独处理对海马脑片强直后长期增强效应的影响。揭示了超低剂量抗体治疗给药所产生变化的可能机制。
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