Kobayashi T, Kida Y
Department of Neurosurgery, Komaki City Hospital, Japan.
Stereotact Funct Neurosurg. 1992;59(1-4):123-7. doi: 10.1159/000098928.
Interstitial hyperthermia of malignant brain tumors has been produced by a heated ferromagnetic implant with a low Curie point. Induction heating of the implant, which is stereotactically implanted in a tumor, is obtained by eddy currents in a high-frequency magnetic field. Safe, repeated and long-term treatment of 35 cases of malignant brain tumors has been done using this system. The overall response rate was 31.4%, but the rate for metastatic brain tumors, deep-seated gliomas and others were 50.0, 36.8 and 33.3%, respectively. Deep-seated gliomas were more effectively treated than superficial gliomas by combination with radiation therapy. The common pathological finding was a clearly demarcated coagulative necrosis of ellipsoid shape around the implant.
利用低居里点的加热铁磁植入物对恶性脑肿瘤进行间质热疗。将植入物立体定向植入肿瘤中，通过高频磁场中的涡流实现对植入物的感应加热。使用该系统已对35例恶性脑肿瘤进行了安全、重复和长期的治疗。总体缓解率为31.4%，但脑转移瘤、深部胶质瘤及其他类型的缓解率分别为50.0%、36.8%和33.3%。深部胶质瘤与放射治疗联合应用时比浅表胶质瘤治疗更有效。常见的病理表现是植入物周围出现界限清晰的椭圆形凝固性坏死。
