Sugiyama K, Sakai T, Fujishima I, Ryu H, Uemura K, Yokoyama T
Department of Neurosurgery, Hamamatsu University School of Medicine, Japan.
Stereotact Funct Neurosurg. 1990;54-55:501-5. doi: 10.1159/000100263.
Laser hyperthermia using Nd-YAG laser was studied experimentally and clinically to treat deep-seated brain tumors. Histological changes, temperature profile, and modification of the blood-brain barrier were studied using cat and rat brains. In a clinical study 5 patients with brain tumors were treated with laser hyperthermia using this computed tomography-stereotactic technique. All tumors of these patients disappeared on computed tomography, and 3 of the 5 patients are still alive without recurrence. It was possible to make optimal lesion and to have accurate peripheral temperature control by using the combination of the Komai stereotactic method and the SLT Nd-YAG laser system. Interstitial laser hyperthermia using this method is easy and safe to use, and it is beneficial to treat deep-seated brain tumors.
对使用钕钇铝石榴石激光进行激光热疗以治疗深部脑肿瘤进行了实验和临床研究。利用猫和大鼠的大脑研究了组织学变化、温度分布以及血脑屏障的改变。在一项临床研究中，使用这种计算机断层扫描立体定向技术对5例脑肿瘤患者进行了激光热疗。这些患者的所有肿瘤在计算机断层扫描上均消失，5例患者中有3例仍存活且无复发。通过结合小牧立体定向方法和SLT钕钇铝石榴石激光系统，可以形成最佳病灶并实现精确的外周温度控制。使用这种方法进行间质激光热疗操作简便且安全，对治疗深部脑肿瘤有益。
