Leslie K S, Gaffney K, Ross C N, Ridley S, Barker T H, Garioch J J
Norfolk & Norwich University Hospital, Norwich, UK.
Clin Exp Dermatol. 2003 Sep;28(5):496-8. doi: 10.1046/j.1365-2230.2003.01336.x.
Dapsone (4,4'-diaminodiphenyl sulphone) is used for a variety of dermatological conditions including immunobullous diseases and urticarial vasculitis. Side-effects are common and include lethargy, headaches, methaemoglobinaemia and haemolysis. Severe adverse effects are rare but the dapsone hypersensitivity syndrome is well recognized. Symptoms include fever, haemolytic anaemia, lymphocytosis and hepatitis. We report a near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis. This diagnosis should be remembered in any patient who becomes unwell whilst taking dapsone.
氨苯砜（4,4'-二氨基二苯砜）用于多种皮肤病，包括免疫性大疱性疾病和荨麻疹性血管炎。副作用很常见，包括嗜睡、头痛、高铁血红蛋白血症和溶血。严重不良反应很少见，但氨苯砜超敏综合征已得到充分认识。症状包括发热、溶血性贫血、淋巴细胞增多和肝炎。我们报告了1例荨麻疹性血管炎患者发生的近乎致命的氨苯砜超敏综合征病例。对于任何在服用氨苯砜期间出现不适的患者，都应考虑这一诊断。
