Pereira Carmen M, Vaz Marina, Kotha Sindhoora, Santosh N H
J Assoc Physicians India. 2014 Aug;62(8):728-31.
Drug hypersensitivity with myocarditis is known to occur with many drugs especially with antiepileptics, sulpha-compounds and daposne. Dapsone (4, 4 diaminodiphenyl sulphone) induced hypersensitivity is known to occur in about 2% of leprosy patients on treatment and an incidence of 1.66% in non-leprosy patients. We report this rare case of dapsone hypersensitivity syndrome in a girl on dapsone who presented with fever, anaemia, jaundice, skin rash, lymphadenopathy, and hepatomegaly and later developed myocarditis. The drug was withdrawn and the patient was treated with steroids. She improved and was discharged. She relapsed after the corticosteroids were discontinued at home.
药物超敏反应合并心肌炎已知会与许多药物相关，尤其是抗癫痫药、磺胺类化合物和氨苯砜。已知氨苯砜（4,4-二氨基二苯砜）引起的超敏反应在接受治疗的麻风病患者中发生率约为2%，在非麻风病患者中的发生率为1.66%。我们报告了一名服用氨苯砜的女孩发生氨苯砜超敏综合征的罕见病例，该女孩出现发热、贫血、黄疸、皮疹、淋巴结病和肝肿大，随后发展为心肌炎。停用该药物后，患者接受了类固醇治疗。她病情好转并出院。在家中停用皮质类固醇后她复发了。
