Zwicker G M, Eyster R C, Sells D M, Gass J H
Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana 46268.
Toxicol Pathol. 1992;20(3 Pt 1):327-40. doi: 10.1177/019262339202000303.
A total of 93 tumors of the epidermis, its appendages, and dermis were observed in 1,433 (717 males, 716 females) rats employed in oncogenicity studies over a 2-yr period. Mammary gland neoplasms will be reported separately. Fifty-seven (61.3%) were epithelial with 49 in males and 8 in females. Keratoacanthoma was the most frequent epithelial neoplasm in males (22) followed by squamous cell carcinoma (11) and papilloma (5). Sebaceous gland neoplasms seen in males (5) included both adenomas (3) and carcinomas (2). In males, there were also 3 trichoepitheliomas, 1 pilomatricoma, 1 basal cell tumor, and 1 malignant melanoma. Of the 8 epithelial neoplasms in females, there were 3 squamous cell carcinomas, 2 keratoacanthomas, and 1 each basal cell tumor, malignant melanoma, and trichoepithelioma. There were 21 mesenchymal neoplasms in males and 15 in females. The most frequent neoplasm was fibroma (7 males, 8 females) followed by lipoma (7 males, 4 females) and fibrosarcoma (4 males, 3 females). One male had a liposarcoma and 2 males each had hemangioma. The total neoplasm incidence of 70/717 (9.8%) in males and 23/716 (3.2%) in females showed that skin neoplasms were 3 time more common in males than in females. Epithelial neoplasms of the skin were 6 times more common in males than in females. Males were more than twice as likely to have epithelial rather than mesenchymal skin neoplasms whereas the reverse was seen in females.
在为期两年的致癌性研究中，对1433只大鼠（717只雄性，716只雌性）进行观察，共发现93例表皮、其附属器及真皮肿瘤。乳腺肿瘤将另行报告。57例（61.3%）为上皮性肿瘤，其中雄性49例，雌性8例。角化棘皮瘤是雄性中最常见的上皮性肿瘤（22例），其次是鳞状细胞癌（11例）和乳头状瘤（5例）。雄性中可见的皮脂腺肿瘤（5例）包括腺瘤（3例）和癌（2例）。雄性中还有3例毛发上皮瘤、1例毛母质瘤、1例基底细胞瘤和1例恶性黑色素瘤。雌性的8例上皮性肿瘤中，有3例鳞状细胞癌、2例角化棘皮瘤，以及各1例基底细胞瘤、恶性黑色素瘤和毛发上皮瘤。雄性有21例间叶性肿瘤，雌性有15例。最常见的肿瘤是纤维瘤（雄性7例，雌性8例），其次是脂肪瘤（雄性7例，雌性4例）和纤维肉瘤（雄性4例，雌性3例）。1只雄性患有脂肪肉瘤，2只雄性各患有血管瘤。雄性的肿瘤总发生率为70/717（9.8%），雌性为23/716（3.2%），表明皮肤肿瘤在雄性中的发生率是雌性的3倍。皮肤上皮性肿瘤在雄性中的发生率是雌性的6倍。雄性患上皮性而非间叶性皮肤肿瘤的可能性是雌性的两倍多，而在雌性中情况则相反。
