原始生殖细胞的发育：斑马鱼视角

Primordial germ-cell development: the zebrafish perspective.

作者信息

Raz Erez

机构信息

Germ Cell Development, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany.

出版信息

Nat Rev Genet. 2003 Sep;4(9):690-700. doi: 10.1038/nrg1154.

DOI:10.1038/nrg1154

PMID:12951570

Abstract

Primordial germ cells follow a characteristic developmental path that is manifested in the specialized regulation of basic cell functions and behaviour. Recent studies in zebrafish have greatly enhanced our understanding of the mode of specification of primordial germ cells, cell-fate maintenance and the migration of these cells towards their target, the gonad, where they differentiate into gametes.

摘要

原始生殖细胞遵循一条独特的发育路径，这在基本细胞功能和行为的特殊调控中得以体现。近期对斑马鱼的研究极大地增进了我们对原始生殖细胞的特化模式、细胞命运维持以及这些细胞向其靶器官——性腺迁移（它们在性腺中分化为配子）的理解。