Raz Erez, Reichman-Fried Michal
Germ Cell Development, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany.
Curr Opin Genet Dev. 2006 Aug;16(4):355-9. doi: 10.1016/j.gde.2006.06.007. Epub 2006 Jun 23.
The migration of zebrafish primordial germ cell towards the region where the gonad develops is guided by the chemokine SDF-1a. Recent studies show that soon after their specification, the cells undergo a series of morphological alterations before they become motile and are able to respond to attractive cues. As migratory cells, primordial germ cells move towards their target while correcting their path upon exiting a cyclic phase in which morphological cell polarity is lost. In the following stages, the cells gather at specific locations and move as cell clusters towards their final target. In all of these stages, zebrafish germ cells respond as individual cells to alterations in the shape of the sdf-1a expression domain, by directed migration towards their target - the position where the gonad develops.
斑马鱼原始生殖细胞向性腺发育区域的迁移是由趋化因子SDF-1a引导的。最近的研究表明，在它们分化后不久，这些细胞在变得可移动并能够对吸引性线索做出反应之前会经历一系列形态变化。作为迁移细胞，原始生殖细胞在退出形态细胞极性丧失的循环阶段后，一边朝着目标移动，一边校正路径。在接下来的阶段，细胞聚集在特定位置，并作为细胞簇朝着最终目标移动。在所有这些阶段中，斑马鱼生殖细胞作为单个细胞，通过向其目标——性腺发育的位置进行定向迁移，对sdf-1a表达域形状的变化做出反应。
