人乳头瘤病毒与人类免疫缺陷病毒合并感染及下生殖道肿瘤形成风险：近期进展综述
Human papillomavirus and HIV coinfection and the risk of neoplasias of the lower genital tract: a review of recent developments.
作者信息
Ferenczy Alex, Coutlée François, Franco Eduardo, Hankins Catherine
机构信息
Department of Pathology, McGill University and Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC.
出版信息
CMAJ. 2003 Sep 2;169(5):431-4.
Abstract
One of the risk factors for human papillomavirus (HPV) infection and subsequent lower genital tract neoplasias and cancers is impaired cell-mediated immunity. HIV-positive women with severe immunosuppression are 5 times more likely than HIV-negative women to have lower genital tract neoplasias. A corresponding increase in the risk of invasive vulvar and anal cancers, but not of cervical cancer, has also been observed among HIV-positive women. Treatment failure and recurrence of neoplasia occur much more frequently among HIV-positive than among HIV-negative women. In this review, we discuss recent advances in the understanding of the relation between HIV and HPV coinfection and the development of lower genital tract neoplasias and cancers in women. In addition, we present strategies for monitoring and treating noninvasive and invasive neoplasias of the lower genital tract in HIV-positive women.
摘要
细胞介导免疫受损是人类乳头瘤病毒（HPV）感染以及随后发生下生殖道肿瘤和癌症的风险因素之一。免疫严重抑制的HIV阳性女性发生下生殖道肿瘤的可能性是HIV阴性女性的5倍。在HIV阳性女性中还观察到浸润性外阴癌和肛门癌风险相应增加，但宫颈癌风险未增加。HIV阳性女性肿瘤的治疗失败和复发比HIV阴性女性更频繁。在本综述中，我们讨论了在理解HIV与HPV合并感染以及女性下生殖道肿瘤和癌症发生之间关系方面的最新进展。此外，我们还介绍了监测和治疗HIV阳性女性下生殖道非侵袭性和侵袭性肿瘤的策略。
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本文引用的文献
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J Low Genit Tract Dis. 2003 Jan;7(1):16-21. doi: 10.1097/00128360-200301000-00005.
2
HAART use in women with HIV and influence on cervical intraepithelial neoplasia: a clinical opinion.高效抗逆转录病毒疗法在感染艾滋病毒女性中的应用及其对宫颈上皮内瘤变的影响：临床观点
J Low Genit Tract Dis. 2002 Apr;6(2):111-5. doi: 10.1097/00128360-200204000-00007.
3
HIV-1 infection and risk of vulvovaginal and perianal condylomata acuminata and intraepithelial neoplasia: a prospective cohort study.人类免疫缺陷病毒1型感染与外阴阴道及肛周尖锐湿疣和上皮内瘤变的风险：一项前瞻性队列研究
Lancet. 2002 Jan 12;359(9301):108-13. doi: 10.1016/S0140-6736(02)07368-3.
4
The effect of highly active antiretroviral therapy on cervical cytologic changes associated with oncogenic HPV among HIV-infected women.高效抗逆转录病毒疗法对HIV感染女性中与致癌性人乳头瘤病毒相关的宫颈细胞学变化的影响。
AIDS. 2001 Nov 9;15(16):2157-64. doi: 10.1097/00002030-200111090-00011.
5
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J Acquir Immune Defic Syndr. 2001 Apr 1;26(4):394-5. doi: 10.1097/00126334-200104010-00022.
6
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CMAJ. 2001 Apr 3;164(7):1017-25.
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J Natl Cancer Inst. 2000 Sep 20;92(18):1500-10. doi: 10.1093/jnci/92.18.1500.
8
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Obstet Gynecol. 2000 Sep;96(3):403-9. doi: 10.1016/s0029-7844(00)00948-0.
9
Anal squamous intraepithelial lesions in human immunodeficiency virus-positive men and women.人类免疫缺陷病毒阳性男性和女性的肛管鳞状上皮内病变
Semin Oncol. 2000 Aug;27(4):471-9.
10
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JAMA. 2000 Feb 23;283(8):1031-7. doi: 10.1001/jama.283.8.1031.
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