CD1d现身：热休克蛋白110在肠道上皮细胞CD1d表达调控中的作用
Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression.
作者信息
Nicchitta Christopher V
机构信息
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
J Clin Invest. 2003 Sep;112(5):646-8. doi: 10.1172/JCI19641.
Abstract
CD1d, a nonclassical MHC class I-like molecule, is prominently expressed on intestinal epithelial cells and is thought to function in the regulation of intestinal intraepithelial lymphocyte activity. Hsp110, an abundant heat shock protein present in essentially all mammalian tissues, has now been shown to upregulate CD1d expression in colonic tissue culture cell lines. Might this abundant chaperone serve an autocrine function in the regulation of CD1d expression?
摘要
CD1d是一种非经典的I类主要组织相容性复合体（MHC）样分子，在肠道上皮细胞中显著表达，被认为在调节肠道上皮内淋巴细胞活性中发挥作用。Hsp110是一种几乎存在于所有哺乳动物组织中的丰富热休克蛋白，现已证明它能上调结肠组织培养细胞系中CD1d的表达。这种丰富的伴侣蛋白在CD1d表达的调节中是否发挥自分泌功能呢？
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