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Local signaling by the EGF receptor.

作者信息

Kempiak Stephan J, Yip Shu-Chin, Backer Jonathan M, Segall Jeffrey E

机构信息

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.

出版信息

J Cell Biol. 2003 Sep 1;162(5):781-7. doi: 10.1083/jcb.200303144.

DOI:10.1083/jcb.200303144
PMID:12952932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2172819/
Abstract

Differing spatial scales of signaling cascades are critical for cell orientation during chemotactic responses. We used biotin EGF bound to streptavidin-coupled magnetic beads to locally stimulate cells overexpressing the EGF receptor. We have found that EGF-induced actin polymerization remains localized even under conditions of receptor overexpression. Conversely, EGF-induced ERK activation spreads throughout the cell body after EGF bead stimulation. The localized actin polymerization is independent of PI3-kinase and rho protein activity and requires Arp2/3 complex and cofilin function. Thus, we find differing spatial scales of signaling from the EGF receptor, supporting models of chemotaxis that integrate short- and long-range signaling.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/b34dfbe543c0/200303144f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/ce381a5da666/200303144f1ac.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/dfee254b57b7/200303144f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/b547b871f380/200303144f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/95a7aeccfefe/200303144f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/b34dfbe543c0/200303144f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/ce381a5da666/200303144f1ac.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/dfee254b57b7/200303144f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/b547b871f380/200303144f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/95a7aeccfefe/200303144f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37e0/2172819/b34dfbe543c0/200303144f5.jpg

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