Bouma I, Pijpe J, Vissink A
Kliniek voor Mondziekten, Kaakchirurgie en Bijzondere Tandheelkunde, Academisch Ziekenhuis Groningen, Postbus 30.001, 9700 RB Groningen.
Ned Tijdschr Tandheelkd. 2003 Aug;110(8):316-20.
Sjögren's syndrome is an auto-immune disease resulting in, among other problems, serious eye and mouth dryness. The course of the disease, especially from an early towards a later phase, is largely unknown. The purpose of this study was to evaluate the symptoms and salivary gland function of Sjögren's syndrome patients, in order to gain insight in the possible progression of the disease. Forty-three patients were followed during a mean period of 3.5 years. Patients with a longer duration of oral symptoms showed more subjective complaints and less salivary flow when compared to patients with recent oral complaints. The differences in both the subjective and objective signs disappeared almost completely during follow-up. From this study it was concluded that Sjögen's syndrome is a progressive disease when diagnosed early. By asking specific questions the dentist can play an important role in early diagnosing the syndrome.
干燥综合征是一种自身免疫性疾病，会导致严重的眼干和口干等问题。该疾病的病程，尤其是从早期到晚期的病程，在很大程度上尚不明确。本研究的目的是评估干燥综合征患者的症状和唾液腺功能，以便深入了解该疾病可能的进展情况。43名患者接受了平均3.5年的随访。与近期有口腔症状的患者相比，有较长时间口腔症状的患者表现出更多主观不适且唾液分泌量更少。在随访期间，主观和客观体征的差异几乎完全消失。从这项研究得出的结论是，干燥综合征在早期诊断时是一种进行性疾病。通过询问特定问题，牙医在该综合征的早期诊断中可以发挥重要作用。
