Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):210-214. Epub 2018 Jul 25.
Mucosal dryness is a key clinical feature in primary Sjögren's syndrome (pSS) and its assessment relies on both objective measurement of residual secretion and subjective symptoms reported by patients. However, while the objective assessment and grading of glandular dysfunction can be easily performed, the spectrum of clinical symptoms encompassed by the terms 'dry eye' and 'dry mouth' is wide and heterogeneous. Therefore, patient reported outcomes (PROs) for dryness in pSS poorly correlate with the amount of glandular secretion. In addition, subjective dryness is not correlated with the severity of systemic disease and severely affects the patient quality of life even in presence of active extraglandular manifestations. The purpose of this review article is to provide an overview of glandular dysfunction in pSS as well as the impact of discrepancy between objective assessment, subjective symptom and extraglandular disease activity on disease management.
黏膜干燥是原发性干燥综合征（pSS）的一个关键临床特征，其评估既依赖于对残留分泌物的客观测量，也依赖于患者报告的主观症状。然而，尽管腺体功能障碍的客观评估和分级可以很容易地进行，但“干眼”和“口干”这两个术语所包含的临床症状范围很广且具有异质性。因此，pSS 患者报告的干燥症状与腺体分泌量相关性差。此外，主观干燥与系统性疾病的严重程度无关，即使存在活动性外分泌腺表现，也会严重影响患者的生活质量。本文综述的目的是概述 pSS 中的腺体功能障碍，以及客观评估、主观症状和外分泌腺疾病活动之间的差异对疾病管理的影响。
