Kierska D, Szymańska H, Maslinski C
Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
Agents Actions. 1992 Nov;37(3-4):227-31. doi: 10.1007/BF02028113.
Histamine (HA) level and its metabolism in adenocarcinoma mammae, spontaneously growing cancer in C3H mice, were examined in relation to the type of tumor, intensity of tumor vascularization and the presence or absence of a secretory function. Histamine concentration being in mammary gland one of the highest among mammalian organs (418 nmol/g) was decreased by 90% in tumor (34 nmol/g). Similarly, histidine decarboxylase (HDC) activity dropped from approximately 7.6 pmol/min/g in normal gland to an undetectable level in adenocarcinoma mammae. Of the two main HA degrading enzymes, namely, diamine oxidase and histamine N-methyl-transferase (HMT), only HMT could be detected in mammary gland, either healthy or neoplastic, and its activity was about 5-fold lower in tumor than in the control tissue (1 nmol/g/min vs. 5.2 nmol/g/min). The pattern of changes in histaminergic parameters evoked by the tumor was similar irrespective of the morphological type it represented, characteristics of its vascular bed or whether or not it showed secretory activity.
研究了组胺（HA）水平及其在C3H小鼠自发性生长的乳腺癌腺癌中的代谢情况，涉及肿瘤类型、肿瘤血管化强度以及是否存在分泌功能。组胺浓度在哺乳动物器官中是乳腺最高之一（418 nmol/g），在肿瘤中降低了90%（34 nmol/g）。同样，组氨酸脱羧酶（HDC）活性从正常腺体中约7.6 pmol/min/g降至乳腺癌腺癌中无法检测到的水平。在两种主要的HA降解酶，即二胺氧化酶和组胺N-甲基转移酶（HMT）中，仅在健康或肿瘤乳腺组织中检测到HMT，其活性在肿瘤中比对照组织低约5倍（1 nmol/g/min对5.2 nmol/g/min）。无论肿瘤代表的形态类型、其血管床特征或是否显示分泌活性，肿瘤引起的组胺能参数变化模式都是相似的。
