Burtin C, Scheinmann P, Salomon J C, Lespinats G, Frayssinet C, Lebel B, Canu P
Br J Cancer. 1981 May;43(5):684-8. doi: 10.1038/bjc.1981.99.
Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing animals for ventral and dorsal skin, skeletal muscle and stomach fundus. Total histamine content was increased in the spleen. In C3H mice with McC3-1 fibrosarcoma, the excision of the tumour or its partial regression by intratumoral injections of corynebacterium parvum induced a reversion to normal values. The tumour thus appears responsible for the increased histamine levels in tissues distant from the tumour.
对携带甲基胆蒽诱导的纤维肉瘤的C3H和C57BL/6小鼠、携带黄曲霉毒素B1诱导的肝癌的Wag大鼠以及携带移植性肝癌的Commentry大鼠的组织组胺水平进行了研究。在荷瘤动物的腹侧和背侧皮肤、骨骼肌和胃底中，组胺水平显著更高（1.5至3倍）。脾脏中的总组胺含量增加。在患有McC3-1纤维肉瘤的C3H小鼠中，切除肿瘤或通过瘤内注射短小棒状杆菌使其部分消退会导致组胺水平恢复正常。因此，肿瘤似乎是导致远离肿瘤的组织中组胺水平升高的原因。
