Lim Kiwon, Ryu Sungpil, Nho Ho-Sung, Choi Sung-Keun, Kwon Taedong, Suh Heajung, So Jaemoo, Tomita Kyoko, Okuhara Yasuhide, Shigematsu Norihiro
Department of Physical Education, Konkuk University, Seoul, Korea.
J Nutr Sci Vitaminol (Tokyo). 2003 Jun;49(3):163-7. doi: 10.3177/jnsv.49.163.
(-)-Hydroxycitric acid (HCA) is a competitive inhibitor of the enzyme ATPcitrate-lyase, which inhibits lipogenesis in the body. Moreover, HCA increases endurance exercise performance in trained mice and athletes. However, had not been investigated in untrained animals and humans. Therefore, we investigated the effects of short-term HCA ingestion on endurance exercise performance and fat metabolism in untrained women. In two experiments designed as a double-blind crossover test, six subjects ingested 250 mg of HCA or placebo (same amount of dextrin) via capsule for 5 d and then participated in cycle ergometer exercise. They cycled at 40% VO2max for 1 h and then the exercise intensity was increased to 60% VO2max until exhaustion on day 5 of each experiment. HCA tended to decrease the respiratory exchange ratio (RER) and carbohydrate oxidation during 1 h of exercise. In addition, exercise time to exhaustion was significantly enhanced (p<0.05). These results suggest that HCA increases fat metabolism, which may be associated with a decrease in glycogen utilization during the same intensity exercise and enhanced exercise performance.
（-）-羟基柠檬酸（HCA）是一种竞争性的ATP柠檬酸裂解酶抑制剂，它可抑制体内脂肪生成。此外，HCA可提高训练有素的小鼠和运动员的耐力运动表现。然而，尚未在未经训练的动物和人类中进行研究。因此，我们研究了短期摄入HCA对未经训练女性耐力运动表现和脂肪代谢的影响。在两项设计为双盲交叉试验的实验中，6名受试者通过胶囊摄入250毫克HCA或安慰剂（等量糊精），持续5天，然后参加自行车测力计运动。在每个实验的第5天，她们以40%的最大摄氧量骑行1小时，然后将运动强度提高到60%的最大摄氧量，直至精疲力竭。HCA在运动1小时期间倾向于降低呼吸交换率（RER）和碳水化合物氧化。此外，力竭运动时间显著延长（p<0.05）。这些结果表明，HCA可增加脂肪代谢，这可能与相同强度运动期间糖原利用率降低和运动表现增强有关。
